The Arctic environment is impacted by multiple stressors such as climate change, pollution, industrialization, shipping and more. The stressors are not acting independently but interact and may trigger cumulative impacts. The coupling between persistent organic pollutants (POPs) and climate change is a concrete example of such complex interactions. Changes in temperature, precipitation, weather events, etc. is likely to influence the mobilization, transport, and fate of POPs, as well as influence the uptake and effect on living organisms. The scientific body of literature on the issue has in recent years been increasing. However, in spite of a better understanding of interaction between multiple stressors, our hypothesis is that the increasing body of science to a limited degree has been reflected in policy and that existing governance frameworks (local, national, regional and global) are inadequate to handle associated risk. Hence, the present study will examine how the Arctic Council (AC), for more than two decades, has brokered Arctic science on multiple stressors, increasingly collaborating with UN, the translation of an assessment report into policy under the Stockholm Convention on POPs and its practical impact on risk management and pollution control. Using case-studies in selected Arctic counties and municipalities, we will furthermore identify the main barriers and opportunities for managing interactive risks at the local level, and analyse the interlinkages between local, national and international levels.